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Refinement of lentiviral vector for improved RNA processing and reduced rates of self inactivation repair

BACKGROUND: Lentiviral gene therapy vectors are now finding clinical application. In order to fully exploit their potential it is important that vectors are made as efficient and as safe as possible. Accordingly, we have modified a previously reported vector to improve RNA processing, minimise Human...

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Detalles Bibliográficos
Autores principales: Koldej, Rachel M, Anson, Donald S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765960/
https://www.ncbi.nlm.nih.gov/pubmed/19811661
http://dx.doi.org/10.1186/1472-6750-9-86