Limited copy number - high resolution melting (LCN-HRM) enables the detection and identification by sequencing of low level mutations in cancer biopsies

BACKGROUND: Mutation detection in clinical tumour samples is challenging when the proportion of tumour cells, and thus mutant alleles, is low. The limited sensitivity of conventional sequencing necessitates the adoption of more sensitive approaches. High resolution melting (HRM) is more sensitive th...

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Detalles Bibliográficos
Autores principales: Do, Hongdo, Dobrovic, Alexander
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766370/
https://www.ncbi.nlm.nih.gov/pubmed/19811662
http://dx.doi.org/10.1186/1476-4598-8-82

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766370/
https://www.ncbi.nlm.nih.gov/pubmed/19811662
http://dx.doi.org/10.1186/1476-4598-8-82

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