Experiences from treatment-predictive KRAS testing; high mutation frequency in rectal cancers from females and concurrent mutations in the same tumor

BACKGROUND: KRAS mutations represent key alterations in colorectal cancer development and lead to constitutive EGFR signaling. Since EGFR inhibition represents a therapeutic strategy in advanced colorectal cancer, KRAS mutation analysis has quickly been introduced as a treatment-predictive test. MET...

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Detalles Bibliográficos
Autores principales: Jönsson, Mats, Ekstrand, Anna, Edekling, Thomas, Eberhard, Jakob, Grabau, Dorthe, Borg, David, Nilbert, Mef
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766396/
https://www.ncbi.nlm.nih.gov/pubmed/19832985
http://dx.doi.org/10.1186/1472-6890-9-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766396/
https://www.ncbi.nlm.nih.gov/pubmed/19832985
http://dx.doi.org/10.1186/1472-6890-9-8

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