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P-Loop Residues Critical for Selectivity in K(+) Channels Fail to Confer Selectivity to Rabbit HCN4 Channels
HCN channels are thought to be structurally similar to K(v) channels, but show much lower selectivity for K(+). The ∼3.3 Å selectivity filter of K(+) channels is formed by the pore-lining sequence XT(V/I)GYG, with X usually T, and is held stable by key residues in the P-loop. Differences in the P-lo...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766643/ https://www.ncbi.nlm.nih.gov/pubmed/19890386 http://dx.doi.org/10.1371/journal.pone.0007712 |