Tolerability and safety of GS-101 eye drops, an antisense oligonucleotide to insulin receptor substrate-1: a ‘first in man’ Phase I investigation

AIMS: GS-101 (GeneSignal, Epalinges, Switzerland) is an antisense oligonucleotide that inhibits the expression of the scaffold protein insulin receptor substrate-1 (IRS-1). Inhibition of IRS-1 results in the prevention of neovascular growth and was shown to prevent the angiogenic process in preclini...

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Detalles Bibliográficos
Autores principales: Kain, Hermann, Goldblum, David, Geudelin, Bernard, Thorin, Eric, Beglinger, Christoph
Formato: Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2009
Materias:
Clinical Trials
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767278/
https://www.ncbi.nlm.nih.gov/pubmed/19694734
http://dx.doi.org/10.1111/j.1365-2125.2009.03450.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767278/
https://www.ncbi.nlm.nih.gov/pubmed/19694734
http://dx.doi.org/10.1111/j.1365-2125.2009.03450.x

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