Design and modification of EGF4KDEL 7Mut, a novel bispecific ligand-directed toxin, with decreased immunogenicity and potent anti-mesothelioma activity

BACKGROUND: Potency, immunogenicity, and toxicity are three problems that limit the use of targeted toxins in solid tumour therapy. METHODS: To address potency, we used genetic engineering to develop a novel bispecific ligand-directed toxin (BLT) called EGF4KDEL, a novel recombinant anti-mesotheliom...

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Detalles Bibliográficos
Autores principales: Stish, B J, Oh, S, Chen, H, Dudek, A Z, Kratzke, R A, Vallera, D A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768099/
https://www.ncbi.nlm.nih.gov/pubmed/19755995
http://dx.doi.org/10.1038/sj.bjc.6605297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768099/
https://www.ncbi.nlm.nih.gov/pubmed/19755995
http://dx.doi.org/10.1038/sj.bjc.6605297

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