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Design and modification of EGF4KDEL 7Mut, a novel bispecific ligand-directed toxin, with decreased immunogenicity and potent anti-mesothelioma activity
BACKGROUND: Potency, immunogenicity, and toxicity are three problems that limit the use of targeted toxins in solid tumour therapy. METHODS: To address potency, we used genetic engineering to develop a novel bispecific ligand-directed toxin (BLT) called EGF4KDEL, a novel recombinant anti-mesotheliom...
Autores principales: | Stish, B J, Oh, S, Chen, H, Dudek, A Z, Kratzke, R A, Vallera, D A |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768099/ https://www.ncbi.nlm.nih.gov/pubmed/19755995 http://dx.doi.org/10.1038/sj.bjc.6605297 |
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