Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets

OBJECTIVE: The G-protein–coupled receptor GPR40 mediates fatty acid potentiation of glucose-stimulated insulin secretion, but its contribution to insulin secretion in vivo and mechanisms of action remain uncertain. This study was aimed to ascertain whether GPR40 controls insulin secretion in vivo an...

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Detalles Bibliográficos
Autores principales: Alquier, Thierry, Peyot, Marie-Line, Latour, Martin G., Kebede, Melkam, Sorensen, Christina M., Gesta, Stephane, Ronald Kahn, C., Smith, Richard D., Jetton, Thomas L., Metz, Thomas O., Prentki, Marc, Poitout, Vincent
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768167/
https://www.ncbi.nlm.nih.gov/pubmed/19720802
http://dx.doi.org/10.2337/db09-0362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768167/
https://www.ncbi.nlm.nih.gov/pubmed/19720802
http://dx.doi.org/10.2337/db09-0362

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