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Expression of the NH(2)-Terminal Fragment of RasGAP in Pancreatic β-Cells Increases Their Resistance to Stresses and Protects Mice From Diabetes

OBJECTIVE: Our laboratory has previously established in vitro that a caspase-generated RasGAP NH(2)-terminal moiety, called fragment N, potently protects cells, including insulinomas, from apoptotic stress. We aimed to determine whether fragment N can increase the resistance of pancreatic β-cells in...

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Detalles Bibliográficos
Autores principales: Yang, Jiang-Yan, Walicki, Jöel, Jaccard, Evrim, Dubuis, Gilles, Bulat, Natasa, Hornung, Jean-Pierre, Thorens, Bernard, Widmann, Christian
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768177/
https://www.ncbi.nlm.nih.gov/pubmed/19696184
http://dx.doi.org/10.2337/db09-0104