NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma

BACKGROUND: Metastatic melanoma is the most deadly form of skin cancer and with an overall 5-year survival rate of <11%, there is an acute need for novel therapeutic strategies. Activating mutations in the BRAF oncogene are present in 50–70% of cases and contribute to tumourigenesis, thus, defini...

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Detalles Bibliográficos
Autores principales: Flockhart, R J, Armstrong, J L, Reynolds, N J, Lovat, P E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768445/
https://www.ncbi.nlm.nih.gov/pubmed/19724275
http://dx.doi.org/10.1038/sj.bjc.6605277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768445/
https://www.ncbi.nlm.nih.gov/pubmed/19724275
http://dx.doi.org/10.1038/sj.bjc.6605277

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