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mRNA Targeting to ER Stress Signaling Sites

Deficiencies in the protein folding capacity of the endoplasmic reticulum (ER) in all eucaryotic cells lead to ER stress and triggers the unfolded protein response (UPR)1–3. ER stress is sensed by Ire1, a transmembrane kinase/endoribonuclease, which initiates the non-conventional splicing of the mRN...

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Detalles Bibliográficos
Autores principales: Aragón, Tomás, van Anken, Eelco, Pincus, David, Serafimova, Iana M., Korennykh, Alexei V., Rubio, Claudia A., Walter, Peter
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768538/
https://www.ncbi.nlm.nih.gov/pubmed/19079237
http://dx.doi.org/10.1038/nature07641