Intrinsic Structural Disorder Confers Cellular Viability on Oncogenic Fusion Proteins

Chromosomal translocations, which often generate chimeric proteins by fusing segments of two distinct genes, represent the single major genetic aberration leading to cancer. We suggest that the unifying theme of these events is a high level of intrinsic structural disorder, enabling fusion proteins...

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Detalles Bibliográficos
Autores principales: Hegyi, Hedi, Buday, László, Tompa, Peter
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768585/
https://www.ncbi.nlm.nih.gov/pubmed/19888473
http://dx.doi.org/10.1371/journal.pcbi.1000552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768585/
https://www.ncbi.nlm.nih.gov/pubmed/19888473
http://dx.doi.org/10.1371/journal.pcbi.1000552

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