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Intrinsic Structural Disorder Confers Cellular Viability on Oncogenic Fusion Proteins
Chromosomal translocations, which often generate chimeric proteins by fusing segments of two distinct genes, represent the single major genetic aberration leading to cancer. We suggest that the unifying theme of these events is a high level of intrinsic structural disorder, enabling fusion proteins...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768585/ https://www.ncbi.nlm.nih.gov/pubmed/19888473 http://dx.doi.org/10.1371/journal.pcbi.1000552 |