The Transcriptional Cofactor Nab2 Is Induced by TGF-β and Suppresses Fibroblast Activation: Physiological Roles and Impaired Expression in Scleroderma

By stimulating collagen synthesis and myofibroblasts differentiation, transforming growth factor-β (TGF- β) plays a pivotal role in tissue repair and fibrosis. The early growth response-1 (Egr-1) transcription factor mediates profibrotic TGF-β responses, and its expression is elevated in biopsies fr...

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Detalles Bibliográficos
Autores principales: Bhattacharyya, Swati, Wei, Jun, Melichian, Denisa S., Milbrandt, Jeffrey, Takehara, Kazuhiko, Varga, John
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768752/
https://www.ncbi.nlm.nih.gov/pubmed/19888474
http://dx.doi.org/10.1371/journal.pone.0007620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768752/
https://www.ncbi.nlm.nih.gov/pubmed/19888474
http://dx.doi.org/10.1371/journal.pone.0007620

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