Cargando…
AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis
Specialized cell types exploit endosomal trafficking to deliver protein cargoes to cell type–specific lysosome-related organelles (LROs), but how endosomes are specified for this function is not known. In this study, we show that the clathrin adaptor AP-1 and the kinesin motor KIF13A together create...
Autores principales: | Delevoye, Cédric, Hurbain, Ilse, Tenza, Danièle, Sibarita, Jean-Baptiste, Uzan-Gafsou, Stéphanie, Ohno, Hiroshi, Geerts, Willie J.C., Verkleij, Arie J., Salamero, Jean, Marks, Michael S., Raposo, Graça |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768840/ https://www.ncbi.nlm.nih.gov/pubmed/19841138 http://dx.doi.org/10.1083/jcb.200907122 |
Ejemplares similares
-
AP-1/KIF13A Blocking Peptides Impair Melanosome Maturation and Melanin Synthesis
por: Campagne, Cécile, et al.
Publicado: (2018) -
Distinct Protein Sorting and Localization to Premelanosomes, Melanosomes, and Lysosomes in Pigmented Melanocytic Cells(✪)
por: Raposo, Graça, et al.
Publicado: (2001) -
BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery
por: Dennis, Megan K., et al.
Publicado: (2015) -
Type II phosphatidylinositol 4-kinases function sequentially in cargo delivery from early endosomes to melanosomes
por: Zhu, Yueyao, et al.
Publicado: (2022) -
Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes
por: Sitaram, Anand, et al.
Publicado: (2012)