A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity

ZAP-70 is critical for T cell receptor (TCR) signaling. Tyrosine to phenylalanine mutations of Y315 and Y319 in ZAP-70 suggest these residues function to recruit downstream effector molecules, but mutagenesis and crystallization studies reveal that these residues also play an important role in autoi...

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Detalles Bibliográficos
Autores principales: Hsu, Lih-Yun, Tan, Ying Xim, Xiao, Zheng, Malissen, Marie, Weiss, Arthur
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768860/
https://www.ncbi.nlm.nih.gov/pubmed/19841086
http://dx.doi.org/10.1084/jem.20082902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768860/
https://www.ncbi.nlm.nih.gov/pubmed/19841086
http://dx.doi.org/10.1084/jem.20082902

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