Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network

We integrate 16 genomic features to construct an evidence-weighted functional-linkage network comprising 21,657 human genes. The functional-linkage network is used to prioritize candidate genes for 110 diseases, and to reliably disclose hidden associations between disease pairs having dissimilar phe...

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Detalles Bibliográficos
Autores principales: Linghu, Bolan, Snitkin, Evan S, Hu, Zhenjun, Xia, Yu, DeLisi, Charles
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768980/
https://www.ncbi.nlm.nih.gov/pubmed/19728866
http://dx.doi.org/10.1186/gb-2009-10-9-r91

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768980/
https://www.ncbi.nlm.nih.gov/pubmed/19728866
http://dx.doi.org/10.1186/gb-2009-10-9-r91

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