Troglitazone reverses the multiple drug resistance phenotype in cancer cells

A major problem in treating cancer is the development of drug resistance. We previously demonstrated doxorubicin (DOX) resistance in K562 human leukemia cells that was associated with upregulation of glyoxalase 1 (GLO-1) and histone H3 expression. The thiazolidinedione troglitazone (TRG) downregulat...

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Detalles Bibliográficos
Autores principales: Davies, Gerald F, Juurlink, Bernhard HJ, Harkness, Troy AA
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2009
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769242/
https://www.ncbi.nlm.nih.gov/pubmed/19920924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769242/
https://www.ncbi.nlm.nih.gov/pubmed/19920924

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