Cargando…

Gemcitabine and Arabinosylcytosin Pharmacogenomics: Genome-Wide Association and Drug Response Biomarkers

Cancer patients show large individual variation in their response to chemotherapeutic agents. Gemcitabine (dFdC) and AraC, two cytidine analogues, have shown significant activity against a variety of tumors. We previously used expression data from a lymphoblastoid cell line-based model system to ide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Liang, Fridley, Brooke L., Kalari, Krishna, Jenkins, Gregory, Batzler, Anthony, Weinshilboum, Richard M., Wang, Liewei
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770319/ https://www.ncbi.nlm.nih.gov/pubmed/19898621 http://dx.doi.org/10.1371/journal.pone.0007765

Ejemplares similares

Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines
por: Li, Liang, et al.
Publicado: (2014)

Multivariate models to detect genomic signatures for a class of drugs: application to thiopurines pharmacogenomics
por: Fridley, B L, et al.
Publicado: (2012)

Identification of genetic variants or genes that are associated with Homoharringtonine (HHT) response through a genome-wide association study in human lymphoblastoid cell lines (LCLs)
por: Tong, Yin, et al.
Publicado: (2015)

Metformin Pharmacogenomics: Biomarkers to Mechanisms
por: Wang, Liewei, et al.
Publicado: (2014)

Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system
por: Jiang, Jing, et al.
Publicado: (2013)

Pharmacogenomics in Practice
por: Wang, Liewei, et al.
Publicado: (2019)

Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study
por: Niu, Nifang, et al.
Publicado: (2012)

Genetic Association Studies of Copy-Number Variation: Should Assignment of Copy Number States Precede Testing?
por: Breheny, Patrick, et al.
Publicado: (2012)

Pharmacogenomics of selective serotonin reuptake inhibitor treatment for major depressive disorder: genome-wide associations and functional genomics
por: Ji, Yuan, et al.
Publicado: (2012)

Pharmacogenomic Discovery to Function and Mechanism: Breast Cancer as a Case Study
por: Wang, Liewei, et al.
Publicado: (2017)

Copy number variation and cytidine analogue cytotoxicity: A genome-wide association approach
por: Kalari, Krishna R, et al.
Publicado: (2010)

Genetic variations associated with gemcitabine treatment outcome in pancreatic cancer
por: Li, Liang, et al.
Publicado: (2016)

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome‐Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2
por: Dudenkov, Tanda M., et al.
Publicado: (2019)

Pathway-Based Analysis of Genome-Wide Association Data Identified SNPs in HMMR as Biomarker for Chemotherapy- Induced Neutropenia in Breast Cancer Patients
por: Bidadi, Behzad, et al.
Publicado: (2018)

Breast cancer chemoprevention pharmacogenomics: Deep sequencing and functional genomics of the ZNF423 and CTSO genes
por: Liu, Duan, et al.
Publicado: (2017)

Contribution of FKBP5 Genetic Variation to Gemcitabine Treatment and Survival in Pancreatic Adenocarcinoma
por: Ellsworth, Katarzyna A., et al.
Publicado: (2013)

Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics study
por: Biernacka, Joanna M., et al.
Publicado: (2021)

Mitochondrial Reactive Oxygen Species Regulate Adipocyte Differentiation of Mesenchymal Stem Cells in Hematopoietic Stress Induced by Arabinosylcytosine
por: Wang, Weimin, et al.
Publicado: (2015)

TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics
por: Gupta, M, et al.
Publicado: (2016)

Identifying the Genetic Variation of Gene Expression Using Gene Sets: Application of Novel Gene Set eQTL Approach to PharmGKB and KEGG
por: Abo, Ryan, et al.
Publicado: (2012)

SLCO1B1: Application and Limitations of Deep Mutational Scanning for Genomic Missense Variant Function
por: Zhang, Lingxin, et al.
Publicado: (2021)

Pharmacogenomics of aromatase inhibitors in postmenopausal breast cancer and additional mechanisms of anastrozole action
por: Cairns, Junmei, et al.
Publicado: (2020)

The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response
por: Biernacka, J M, et al.
Publicado: (2015)

The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response
por: Biernacka, J M, et al.
Publicado: (2016)

Leveraging an Electronic Health Record-Linked Biorepository to Generate a Metformin Pharmacogenomics Hypothesis
por: Breitenstein, Matthew K., et al.
Publicado: (2015)

Localization of Association Signal from Risk and Protective Variants in Sequencing Studies
por: Brisbin, Abra, et al.
Publicado: (2012)

Impact of Pharmacogenomic Information on Values of Care and Quality of Life Associated with Codeine and Tramadol-Related Adverse Drug Events
por: Zhu, Ye, et al.
Publicado: (2021)

Use of the gamma method for self-contained gene-set analysis of SNP data
por: Biernacka, Joanna M, et al.
Publicado: (2012)

Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation
por: Cairns, Junmei, et al.
Publicado: (2018)

FKBP5 as a Selection Biomarker for Gemcitabine and Akt Inhibitors in Treatment of Pancreatic Cancer
por: Hou, Junmei, et al.
Publicado: (2012)

CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants
por: Zhang, Lingxin, et al.
Publicado: (2020)

Bayesian Machine Learning Enables Identification of Transcriptional Network Disruptions Associated with Drug-Resistant Prostate Cancer
por: Blatti, Charles, et al.
Publicado: (2023)

A model-based cost-effectiveness analysis of pharmacogenomic panel testing in cardiovascular disease management: preemptive, reactive, or none?
por: Zhu, Ye, et al.
Publicado: (2020)

Pharmacogenomic Biomarkers
por: Kirkwood, Sandra C., et al.
Publicado: (2002)

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1
por: Cairns, Junmei, et al.
Publicado: (2019)

Systematic review of the evidence on the cost-effectiveness of pharmacogenomics-guided treatment for cardiovascular diseases
por: Zhu, Ye, et al.
Publicado: (2019)

Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy?
por: Ueno, H, et al.
Publicado: (2007)

Leveraging multi-source to resolve inconsistency across pharmacogenomic datasets in drug sensitivity prediction
por: Das, Trisha, et al.
Publicado: (2023)

Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics
por: Liu, Duan, et al.
Publicado: (2018)

Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer
por: Athreya, Arjun P., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_8fosmc6c6if0mqu2bqcnde7aer