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The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors
BACKGROUND: Anti-cancer drugs access solid tumors via blood vessels, and must penetrate tumor tissue to reach all cancer cells. Previous studies have demonstrated steep gradients of decreasing doxorubicin fluorescence with increasing distance from blood vessels, such that many tumor cells are not ex...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770566/ https://www.ncbi.nlm.nih.gov/pubmed/19807929 http://dx.doi.org/10.1186/1471-2407-9-356 |