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RNA polymerase III can drive polycistronic expression of functional interfering RNAs designed to resemble microRNAs
In both research and therapeutic applications of RNA interference, it is often advantageous to silence several targets simultaneously. Toward this end, several groups have developed vectors that utilize the model of endogenously encoded micro (mi) RNAs, where a single RNA polymerase II promoter can...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770651/ https://www.ncbi.nlm.nih.gov/pubmed/19679642 http://dx.doi.org/10.1093/nar/gkp657 |