A dominant negative mutant of the E. coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit

Escherichia coli DbpA is an ATP-dependent RNA helicase with specificity for hairpin 92 of 23S ribosomal RNA, an important part of the peptidyl transferase center. The R331A active site mutant of DbpA confers a dominant slow growth and cold sensitive phenotype when overexpressed in E. coli containing...

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Detalles Bibliográficos
Autores principales: Sharpe Elles, Lisa M., Sykes, Michael T., Williamson, James R., Uhlenbeck, Olke C.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770675/
https://www.ncbi.nlm.nih.gov/pubmed/19734347
http://dx.doi.org/10.1093/nar/gkp711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770675/
https://www.ncbi.nlm.nih.gov/pubmed/19734347
http://dx.doi.org/10.1093/nar/gkp711

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