Conformational inhibition of the HCV IRES RNA

The internal ribosome entry site (IRES), a highly conserved structured element of the hepatitis C virus genomic RNA, is an attractive target for antiviral drugs. Here we show that benzimidazole inhibitors of the HCV replicon act by conformational induction of a widened interhelical angle in the IRES...

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Detalles Bibliográficos
Autores principales: Parsons, Jerod, Castaldi, M. Paola, Dutta, Sanjay, Dibrov, Sergey M., Wyles, David L., Hermann, Thomas
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770845/
https://www.ncbi.nlm.nih.gov/pubmed/19767736
http://dx.doi.org/10.1038/nchembio.217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770845/
https://www.ncbi.nlm.nih.gov/pubmed/19767736
http://dx.doi.org/10.1038/nchembio.217

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