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Conformational inhibition of the HCV IRES RNA
The internal ribosome entry site (IRES), a highly conserved structured element of the hepatitis C virus genomic RNA, is an attractive target for antiviral drugs. Here we show that benzimidazole inhibitors of the HCV replicon act by conformational induction of a widened interhelical angle in the IRES...
Autores principales: | Parsons, Jerod, Castaldi, M. Paola, Dutta, Sanjay, Dibrov, Sergey M., Wyles, David L., Hermann, Thomas |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770845/ https://www.ncbi.nlm.nih.gov/pubmed/19767736 http://dx.doi.org/10.1038/nchembio.217 |
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