A small molecule that binds Hedgehog and blocks its signaling in human cells

Small-molecule inhibition of extracellular proteins that activate membrane receptors has proved to be extremely challenging. Diversity-oriented synthesis and small-molecule microarrays enabled the discovery of robotnikinin, a small molecule that binds the extracellular Sonic Hedgehog (Shh) protein a...

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Detalles Bibliográficos
Autores principales: Stanton, Benjamin Z., Peng, Lee F., Maloof, Nicole, Nakai, Kazuo, Wang, Xiang, Herlihy, Kara M., Duffner, Jay L., Taveras, Kennedy M., Hyman, Joel M., Lee, Sam W., Koehler, Angela N., Chen, James K., Fox, Julia L., Mandinova, Anna, Schreiber, Stuart L.
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770933/
https://www.ncbi.nlm.nih.gov/pubmed/19151731
http://dx.doi.org/10.1038/nchembio.142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770933/
https://www.ncbi.nlm.nih.gov/pubmed/19151731
http://dx.doi.org/10.1038/nchembio.142

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