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Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase
BACKGROUND: The 18 residue tail abutting the SH3 fold that comprises the heart of the C-terminal domain is the only part of HIV-1 integrase yet to be visualized by structural biology. To ascertain the role of the tail region in integrase function and HIV-1 replication, a set of deletion mutants that...
Autores principales: | Dar, Mohd J, Monel, Blandine, Krishnan, Lavanya, Shun, Ming-Chieh, Di Nunzio, Francesca, Helland, Dag E, Engelman, Alan |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770994/ https://www.ncbi.nlm.nih.gov/pubmed/19840380 http://dx.doi.org/10.1186/1742-4690-6-94 |
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