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Evidence for Impaired CARD15 Signalling in Crohn's Disease without Disease Linked Variants
BACKGROUND: Sensing of muramyl dipeptide (MDP) is impaired in Crohn's disease (CD) patients with disease-linked variants of the CARD15 (caspase activation and recruitment domain 15) gene. Animal studies suggest that normal CARD15 signalling prevents inflammatory bowel disease, and may be import...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771351/ https://www.ncbi.nlm.nih.gov/pubmed/19907652 http://dx.doi.org/10.1371/journal.pone.0007794 |