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Evidence for Impaired CARD15 Signalling in Crohn's Disease without Disease Linked Variants

BACKGROUND: Sensing of muramyl dipeptide (MDP) is impaired in Crohn's disease (CD) patients with disease-linked variants of the CARD15 (caspase activation and recruitment domain 15) gene. Animal studies suggest that normal CARD15 signalling prevents inflammatory bowel disease, and may be import...

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Detalles Bibliográficos
Autores principales:	Seidelin, Jakob Benedict, Broom, Oliver Jay, Olsen, Jørgen, Nielsen, Ole Haagen
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771351/ https://www.ncbi.nlm.nih.gov/pubmed/19907652 http://dx.doi.org/10.1371/journal.pone.0007794

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