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Targeted Deletion of p73 in Mice Reveals Its Role in T Cell Development and Lymphomagenesis
Transcriptional silencing of the p73 gene through methylation has been demonstrated in human leukemias and lymphomas. However, the role of p73 in the malignant process remains to be explored. We show here that p73 acts as a T cell-specific tumor suppressor in a genetically defined mouse model, and t...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771421/ https://www.ncbi.nlm.nih.gov/pubmed/19907659 http://dx.doi.org/10.1371/journal.pone.0007784 |