Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing

Immunoglobulin secretion is modulated by a competition between use of a weak promoter proximal poly(A) site and a non-consensus splice site in the last secretory-specific exon of the heavy chain pre-mRNA. RNA polymerase II transcription elongation factor ELL2, induced in plasma cells, enhanced both...

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Detalles Bibliográficos
Autores principales: Martincic, Kathleen, Alkan, Serkan A., Cheatle, Alys, Borghesi, Lisa, Milcarek, Christine
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771556/
https://www.ncbi.nlm.nih.gov/pubmed/19749764
http://dx.doi.org/10.1038/ni.1786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771556/
https://www.ncbi.nlm.nih.gov/pubmed/19749764
http://dx.doi.org/10.1038/ni.1786

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