Cargando…

Genotyping of Genetically Monomorphic Bacteria: DNA Sequencing in Mycobacterium tuberculosis Highlights the Limitations of Current Methodologies

Because genetically monomorphic bacterial pathogens harbour little DNA sequence diversity, most current genotyping techniques used to study the epidemiology of these organisms are based on mobile or repetitive genetic elements. Molecular markers commonly used in these bacteria include Clustered Regu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Comas, Iñaki, Homolka, Susanne, Niemann, Stefan, Gagneux, Sebastien
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772813/ https://www.ncbi.nlm.nih.gov/pubmed/19915672 http://dx.doi.org/10.1371/journal.pone.0007815

Ejemplares similares

Genetic diversity within Mycobacterium tuberculosis complex impacts on the accuracy of genotypic pyrazinamide drug-susceptibility assay
por: Köser, Claudio U., et al.
Publicado: (2014)

Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved
por: Comas, Iñaki, et al.
Publicado: (2010)

Mapping of Genotype–Phenotype Diversity among Clinical Isolates of Mycobacterium tuberculosis by Sequence-Based Transcriptional Profiling
por: Rose, Graham, et al.
Publicado: (2013)

Evaluation of Customised Lineage-Specific Sets of MIRU-VNTR Loci for Genotyping Mycobacterium tuberculosis Complex Isolates in Ghana
por: Asante-Poku, Adwoa, et al.
Publicado: (2014)

Human Macrophage Responses to Clinical Isolates from the Mycobacterium tuberculosis Complex Discriminate between Ancient and Modern Lineages
por: Portevin, Damien, et al.
Publicado: (2011)

The Past and Future of Tuberculosis Research
por: Comas, Iñaki, et al.
Publicado: (2009)

High Functional Diversity in Mycobacterium tuberculosis Driven by Genetic Drift and Human Demography
por: Hershberg, Ruth, et al.
Publicado: (2008)

Comment on: Characterization of the embB gene in Mycobacterium tuberculosis isolates from Barcelona and rapid detection of main mutations related to ethambutol resistance using a low-density DNA array
por: Köser, Claudio U., et al.
Publicado: (2014)

High Sequence Variability of the ppE18 Gene of Clinical Mycobacterium tuberculosis Complex Strains Potentially Impacts Effectivity of Vaccine Candidate M72/AS01E
por: Homolka, Susanne, et al.
Publicado: (2016)

Novel Mycobacterium tuberculosis Complex Isolate from a Wild Chimpanzee
por: Coscolla, Mireia, et al.
Publicado: (2013)

MIRU-VNTRplus: a web tool for polyphasic genotyping of Mycobacterium tuberculosis complex bacteria
por: Weniger, Thomas, et al.
Publicado: (2010)

Wollamide Cyclic Hexapeptides Synergize with Established and New Tuberculosis Antibiotics in Targeting Mycobacterium tuberculosis
por: Rollo, Rachel F., et al.
Publicado: (2023)

Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex
por: Chiner-Oms, Álvaro, et al.
Publicado: (2019)

Functional Genetic Diversity among Mycobacterium tuberculosis Complex Clinical Isolates: Delineation of Conserved Core and Lineage-Specific Transcriptomes during Intracellular Survival
por: Homolka, Susanne, et al.
Publicado: (2010)

High Resolution Discrimination of Clinical Mycobacterium tuberculosis Complex Strains Based on Single Nucleotide Polymorphisms
por: Homolka, Susanne, et al.
Publicado: (2012)

Whole-genome sequencing of rifampicin-resistant M. tuberculosis strains identifies compensatory mutations in RNA polymerase
por: Comas, Iñaki, et al.
Publicado: (2011)

The Troika Host–Pathogen–Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes
por: Bastos, Helder Novais, et al.
Publicado: (2018)

Two New Rapid SNP-Typing Methods for Classifying Mycobacterium tuberculosis Complex into the Main Phylogenetic Lineages
por: Stucki, David, et al.
Publicado: (2012)

Evolutionary forces in Mycobacterium tuberculosis: implications for product development
por: Gagneux, Sebastien
Publicado: (2010)

Survival of hypoxia-induced dormancy is not a common feature of all strains of the Mycobacterium tuberculosis complex
por: Tizzano, Barbara, et al.
Publicado: (2021)

Co-evolution of Mycobacterium tuberculosis and Homo sapiens
por: Brites, Daniela, et al.
Publicado: (2015)

High genetic diversity among Mycobacterium tuberculosis complex strains from Sierra Leone
por: Homolka, Susanne, et al.
Publicado: (2008)

The molecular clock of Mycobacterium tuberculosis
por: Menardo, Fabrizio, et al.
Publicado: (2019)

Molecular Epidemiology of Mycobacterium tuberculosis Complex Strains in Urban and Slum Settings of Nairobi, Kenya
por: Kerubo, Glennah, et al.
Publicado: (2022)

Genotypic and phenotypic diversity of Mycobacterium tuberculosis complex genotypes prevalent in West Africa
por: Osei-Wusu, Stephen, et al.
Publicado: (2021)

Multiple Merger Genealogies in Outbreaks of Mycobacterium tuberculosis
por: Menardo, Fabrizio, et al.
Publicado: (2020)

Out-of-Africa migration and Neolithic co-expansion of Mycobacterium tuberculosis with modern humans
por: Comas, Iñaki, et al.
Publicado: (2013)

Evaluation of spoligotyping, SNPs and customised MIRU-VNTR combination for genotyping Mycobacterium tuberculosis clinical isolates in Madagascar
por: Rasoahanitralisoa, Rondroarivelo, et al.
Publicado: (2017)

Population Genomics of Mycobacterium tuberculosis in Ethiopia Contradicts the Virgin Soil Hypothesis for Human Tuberculosis in Sub-Saharan Africa
por: Comas, Iñaki, et al.
Publicado: (2015)

Genomic Diversity among Drug Sensitive and Multidrug Resistant Isolates of Mycobacterium tuberculosis with Identical DNA Fingerprints
por: Niemann, Stefan, et al.
Publicado: (2009)

Transmission Dynamics of a Mycobacterium tuberculosis Complex Outbreak in an Indigenous Population in the Colombian Amazon Region
por: Pérez-Llanos, Francy J., et al.
Publicado: (2023)

The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosis
por: Castro, Rhastin A D, et al.
Publicado: (2020)

Lack of methoxy-mycolates characterizes the geographically restricted lineage 7 of Mycobacterium tuberculosis complex
por: Hailu, Elena, et al.
Publicado: (2023)

Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex
por: Chiner-Oms, Á., et al.
Publicado: (2019)

Monomorphic Ventricular Tachycardia
por: Singh, Amandeep
Publicado: (2008)

Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis
por: Young, Douglas B., et al.
Publicado: (2015)

Genomic analyses of Mycobacterium tuberculosis from human lung resections reveal a high frequency of polyclonal infections
por: Moreno-Molina, Miguel, et al.
Publicado: (2021)

Clade-Specific Virulence Patterns of Mycobacterium tuberculosis Complex Strains in Human Primary Macrophages and Aerogenically Infected Mice
por: Reiling, Norbert, et al.
Publicado: (2013)

Mycobacterium africanum—Review of an Important Cause of Human Tuberculosis in West Africa
por: de Jong, Bouke C., et al.
Publicado: (2010)

Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity
por: Copin, Richard, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kjuveuqcpio5e7rek50ndtcf94