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Disruption of Mitochondrial DNA Replication in Drosophila Increases Mitochondrial Fast Axonal Transport In Vivo

Mutations in mitochondrial DNA polymerase (pol γ) cause several progressive human diseases including Parkinson's disease, Alper's syndrome, and progressive external ophthalmoplegia. At the cellular level, disruption of pol γ leads to depletion of mtDNA, disrupts the mitochondrial respirato...

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Detalles Bibliográficos
Autores principales: Baqri, Rehan M., Turner, Brittany A., Rheuben, Mary B., Hammond, Bradley D., Kaguni, Laurie S., Miller, Kyle E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773408/
https://www.ncbi.nlm.nih.gov/pubmed/19924234
http://dx.doi.org/10.1371/journal.pone.0007874