Immunoproteasome Overexpression Underlies the Pathogenesis of Thyroid Oncocytes and Primary Hypothyroidism: Studies in Humans and Mice

BACKGROUND: Oncocytes of the thyroid gland (Hürthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown. METHODOLOGY/PRINCIPAL FINDIN...

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Detalles Bibliográficos
Autores principales: Kimura, Hiroaki J., Chen, Cindy Y., Tzou, Shey-Cherng, Rocchi, Roberto, Landek-Salgado, Melissa A., Suzuki, Koichi, Kimura, Miho, Rose, Noel R., Caturegli, Patrizio
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773418/
https://www.ncbi.nlm.nih.gov/pubmed/19924240
http://dx.doi.org/10.1371/journal.pone.0007857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773418/
https://www.ncbi.nlm.nih.gov/pubmed/19924240
http://dx.doi.org/10.1371/journal.pone.0007857

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