Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment

Hutchinson-Gilford progeria (HGPS) is a premature aging syndrome associated with LMNA mutations. Progeria cells bearing the G608G LMNA mutation are characterized by accumulation of a mutated lamin A precursor (progerin), nuclear dysmorphism and chromatin disorganization. In cultured HGPS fibroblasts...

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Detalles Bibliográficos
Autores principales: Columbaro, M., Capanni, C., Mattioli, E., Novelli, G., Parnaik, V. K., Squarzoni, S., Maraldi, N. M., Lattanzi, G.
Formato: Texto
Lenguaje:English
Publicado: Birkhäuser-Verlag 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773834/
https://www.ncbi.nlm.nih.gov/pubmed/16261260
http://dx.doi.org/10.1007/s00018-005-5318-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773834/
https://www.ncbi.nlm.nih.gov/pubmed/16261260
http://dx.doi.org/10.1007/s00018-005-5318-6

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