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SMF-1, SMF-2 and SMF-3 DMT1 Orthologues Regulate and Are Regulated Differentially by Manganese Levels in C. elegans

Manganese (Mn) is an essential metal that can exert toxic effects at high concentrations, eventually leading to Parkinsonism. A major transporter of Mn in mammals is the divalent-metal transporter (DMT1). We characterize here DMT1-like proteins in the nematode C. elegans, which regulate and are regu...

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Detalles Bibliográficos
Autores principales: Au, Catherine, Benedetto, Alexandre, Anderson, Joel, Labrousse, Arnaud, Erikson, Keith, Ewbank, Jonathan J., Aschner, Michael
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773845/
https://www.ncbi.nlm.nih.gov/pubmed/19924247
http://dx.doi.org/10.1371/journal.pone.0007792