Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation

In prion diseases, the cellular form of the prion protein, PrP(C), undergoes a conformational conversion to the infectious isoform, PrP(Sc). PrP(C) associates with lipid rafts through its glycosyl-phosphatidylinositol (GPI) anchor and a region in its N-terminal domain which also binds to heparan sul...

Descripción completa

Detalles Bibliográficos
Autores principales: Taylor, David R., Whitehouse, Isobel J., Hooper, Nigel M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773931/
https://www.ncbi.nlm.nih.gov/pubmed/19936054
http://dx.doi.org/10.1371/journal.ppat.1000666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773931/
https://www.ncbi.nlm.nih.gov/pubmed/19936054
http://dx.doi.org/10.1371/journal.ppat.1000666

Ejemplares similares