Cargando…
Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation
In prion diseases, the cellular form of the prion protein, PrP(C), undergoes a conformational conversion to the infectious isoform, PrP(Sc). PrP(C) associates with lipid rafts through its glycosyl-phosphatidylinositol (GPI) anchor and a region in its N-terminal domain which also binds to heparan sul...
| Autores principales: | , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773931/ https://www.ncbi.nlm.nih.gov/pubmed/19936054 http://dx.doi.org/10.1371/journal.ppat.1000666 |