Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β(42/40) Ratio

BACKGROUND: Presenilin 1(PS1) is the catalytic subunit of γ-secretase, the enzyme responsible for the Aβ C-terminal cleavage site, which results in the production of Aβ peptides of various lengths. Production of longer forms of the Aβ peptide occur in patients with autosomal dominant Alzheimer disea...

Descripción completa

Detalles Bibliográficos
Autores principales: Uemura, Kengo, Lill, Christina M., Li, Xuejing, Peters, Jessica A., Ivanov, Alexander, Fan, Zhanyun, DeStrooper, Bart, Bacskai, Brian J., Hyman, Bradley T., Berezovska, Oksana
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773935/
https://www.ncbi.nlm.nih.gov/pubmed/19924286
http://dx.doi.org/10.1371/journal.pone.0007893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773935/
https://www.ncbi.nlm.nih.gov/pubmed/19924286
http://dx.doi.org/10.1371/journal.pone.0007893

Ejemplares similares