Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia

Fusion proteins composed of the histone methyltransferase mixed-lineage leukemia (MLL) and a variety of unrelated fusion partners are highly leukemogenic. Despite their prevalence, particularly in pediatric acute leukemia, many molecular details of their transforming mechanism are unknown. Here, we...

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Detalles Bibliográficos
Autores principales: Mueller, Dorothee, García-Cuéllar, María-Paz, Bach, Christian, Buhl, Sebastian, Maethner, Emanuel, Slany, Robert K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774266/
https://www.ncbi.nlm.nih.gov/pubmed/19956800
http://dx.doi.org/10.1371/journal.pbio.1000249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774266/
https://www.ncbi.nlm.nih.gov/pubmed/19956800
http://dx.doi.org/10.1371/journal.pbio.1000249

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