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Three Distinct Domains Contribute to Nuclear Transport of Murine Foxp3

Foxp3, a 47-kDa transcription factor, is necessary for the function of CD4+CD25+ regulatory T cells (Tregs), with an essential role in the control of self-reactive T cells and in preventing autoimmunity. Activation of Tregs by TCR engagement results in upregulation of Foxp3 expression, followed by i...

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Detalles Bibliográficos
Autores principales: Hancock, Wayne W., Özkaynak, Engin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774276/
https://www.ncbi.nlm.nih.gov/pubmed/19924293
http://dx.doi.org/10.1371/journal.pone.0007890