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Three Distinct Domains Contribute to Nuclear Transport of Murine Foxp3
Foxp3, a 47-kDa transcription factor, is necessary for the function of CD4+CD25+ regulatory T cells (Tregs), with an essential role in the control of self-reactive T cells and in preventing autoimmunity. Activation of Tregs by TCR engagement results in upregulation of Foxp3 expression, followed by i...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774276/ https://www.ncbi.nlm.nih.gov/pubmed/19924293 http://dx.doi.org/10.1371/journal.pone.0007890 |