The Background of Mitochondrial DNA Haplogroup J Increases the Sensitivity of Leber's Hereditary Optic Neuropathy Cells to 2,5-Hexanedione Toxicity

Leber's hereditary optic neuropathy (LHON) is a maternally inherited blinding disease due to mitochondrial DNA (mtDNA) point mutations in complex I subunit genes, whose incomplete penetrance has been attributed to both genetic and environmental factors. Indeed, the mtDNA background defined as h...

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Detalles Bibliográficos
Autores principales: Ghelli, Anna, Porcelli, Anna Maria, Zanna, Claudia, Vidoni, Sara, Mattioli, Stefano, Barbieri, Anna, Iommarini, Luisa, Pala, Maria, Achilli, Alessandro, Torroni, Antonio, Rugolo, Michela, Carelli, Valerio
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774515/
https://www.ncbi.nlm.nih.gov/pubmed/19936068
http://dx.doi.org/10.1371/journal.pone.0007922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774515/
https://www.ncbi.nlm.nih.gov/pubmed/19936068
http://dx.doi.org/10.1371/journal.pone.0007922

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