Fluorescent Cascade and Direct Assays for Characterization of RAF Signaling Pathway Inhibitors

RAF kinases are part of a conserved signaling pathway that impacts cell growth, differentiation, and survival, and RAF pathway dysregulation is an attractive target for therapeutic intervention. We describe two homogeneous fluorescent formats that distinguish RAF pathway inhibitors from direct RAF k...

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Detalles Bibliográficos
Autores principales: Kupcho, Kevin R, Bruinsma, Rica, Hallis, Tina M, Lasky, David A, Somberg, Richard L, Turek-Etienne, Tammy, Vogel, Kurt W, Huwiler, Kristin G
Formato: Texto
Lenguaje:English
Publicado: Bentham Science Publishers Ltd. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774691/
https://www.ncbi.nlm.nih.gov/pubmed/20161827
http://dx.doi.org/10.2174/1875397300801010043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774691/
https://www.ncbi.nlm.nih.gov/pubmed/20161827
http://dx.doi.org/10.2174/1875397300801010043

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