Cargando…

Fluorescent Cascade and Direct Assays for Characterization of RAF Signaling Pathway Inhibitors

RAF kinases are part of a conserved signaling pathway that impacts cell growth, differentiation, and survival, and RAF pathway dysregulation is an attractive target for therapeutic intervention. We describe two homogeneous fluorescent formats that distinguish RAF pathway inhibitors from direct RAF k...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kupcho, Kevin R, Bruinsma, Rica, Hallis, Tina M, Lasky, David A, Somberg, Richard L, Turek-Etienne, Tammy, Vogel, Kurt W, Huwiler, Kristin G
Formato:	Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers Ltd. 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774691/ https://www.ncbi.nlm.nih.gov/pubmed/20161827 http://dx.doi.org/10.2174/1875397300801010043

Ejemplares similares

Homogenous Fluorescent Assays for Characterizing Small-Molecule Activators of AMP-Activated Protein Kinase (AMPK)
por: Reichling, Laurie J, et al.
Publicado: (2008)

Direct Targeting of the Raf-MEK-ERK Signaling Cascade Inhibits Neuroblastoma Growth
por: Chilamakuri, Rameswari, et al.
Publicado: (2022)

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
por: Jin, Ting, et al.
Publicado: (2017)

Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
por: Ozkan-Dagliyan, Irem, et al.
Publicado: (2020)

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay
por: Koszela, Joanna, et al.
Publicado: (2018)

Localization dynamics of endogenous fluorescently labeled RAF1 in EGF-stimulated cells
por: Surve, Sachin V., et al.
Publicado: (2019)

A RAF-SnRK2 kinase cascade mediates early osmotic stress signaling in higher plants
por: Lin, Zhen, et al.
Publicado: (2020)

Targeting the Raf kinases in human cancer: the Raf dimer dilemma
por: Durrant, David E, et al.
Publicado: (2018)

A real-time, bioluminescent annexin V assay for the assessment of apoptosis
por: Kupcho, Kevin, et al.
Publicado: (2018)

“RAF” neighborhood: Protein–protein interaction in the Raf/Mek/Erk pathway
por: Cseh, Botond, et al.
Publicado: (2014)

Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade
por: Marjuki, Henju, et al.
Publicado: (2007)

MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells
por: Estrada, Charlène, et al.
Publicado: (2022)

RAF inhibitors transactivate RAF dimers and ERK signaling in cells with wild-type BRAF
por: Poulikakos, Poulikos I., et al.
Publicado: (2010)

Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors
por: Marusiak, Anna A., et al.
Publicado: (2014)

Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain
por: Travers, Timothy, et al.
Publicado: (2018)

Characterization of the RAS/RAF/ERK Signal Cascade as a Novel Regulating Factor in Alpha-Amanitin-Induced Cytotoxicity in Huh-7 Cells
por: Kim, Doeun, et al.
Publicado: (2022)

The sodium channel subunit SCNN1B suppresses colorectal cancer via suppression of active c-Raf and MAPK signaling cascade
por: Qian, Yun, et al.
Publicado: (2022)

Homogeneous Dual-Parametric-Coupled Assay for Simultaneous Nucleotide Exchange and KRAS/RAF-RBD Interaction Monitoring
por: Kopra, Kari, et al.
Publicado: (2020)

Raf-1 regulates migration
por: Tuma, Rabiya S.
Publicado: (2005)

Resistance to RAF inhibitors revisited
por: Hartsough, Edward, et al.
Publicado: (2013)

Arabidopsis Raf-Like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling
por: Nguyen, Quy Thi Cam, et al.
Publicado: (2019)

Crystal Structure Reveals the Full Ras–Raf Interface and Advances Mechanistic Understanding of Raf Activation
por: Cookis, Trinity, et al.
Publicado: (2021)

Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib
por: Tkacik, Emre, et al.
Publicado: (2023)

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response
por: McCubrey, James A., et al.
Publicado: (2012)

Two-Component Direct Fluorescent-Antibody Assay for Rapid Identification of Bacillus anthracis
por: De, Barun K., et al.
Publicado: (2002)

Design and Performance of a DSP Based Neutron Chopper Phase Controller
por: Merl, R, et al.
Publicado: (2001)

Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
por: Bhargava, Ajay, et al.
Publicado: (2016)

A Combination of Conformation-Specific RAF Inhibitors Overcome Drug Resistance Brought about by RAF Overexpression
por: Imoto, Hiroaki, et al.
Publicado: (2023)

Molecular Modeling Unveils the Effective Interaction of B-RAF Inhibitors with Rare B-RAF Insertion Variants
por: Scaini, Maria Chiara, et al.
Publicado: (2023)

Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure
por: Kramer, Boris W, et al.
Publicado: (2004)

A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis
por: Jeric, Ines, et al.
Publicado: (2016)

Mechanisms of resistance to RAF inhibitors in melanoma
por: Aplin, Andrew E., et al.
Publicado: (2011)

B-RAF unlocks axon regeneration
por: Cavalli, Valeria, et al.
Publicado: (2014)

The mechanism of Raf activation through dimerization
por: Zhang, Mingzhen, et al.
Publicado: (2021)

Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation
por: Jossé, Rozenn, et al.
Publicado: (2015)

PDCD6 cooperates with C-Raf to facilitate colorectal cancer progression via Raf/MEK/ERK activation
por: Wang, Xiaojuan, et al.
Publicado: (2020)

PLX8394, a RAF inhibitor, inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling
por: Wu, Chengyuan, et al.
Publicado: (2023)

Performance of the Syva Direct Fluorescent Antibody Assay for Chlamydia in a Low-Prevalence Population
por: Reedy, Mark B., et al.
Publicado: (1993)

A Label-Free and Sensitive Fluorescent Qualitative Assay for Bisphenol A Based on Rolling Circle Amplification/Exonuclease III-Combined Cascade Amplification
por: Li, Xia, et al.
Publicado: (2016)

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis
por: Fritsche-Guenther, Raphaela, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nnc7fona91goiheded816k0n8u