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Generation and Initial Characterization of FDD Knock In Mice
BACKGROUND: Mutations in the integral membrane protein 2B [1], also known as BRI(2) [2], a type II trans-membrane domain protein cause two autosomal dominant neurodegenerative diseases, Familial British and Danish Dementia [3]. In these conditions, accumulation of a C-terminal peptide (ABri and ADan...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774945/ https://www.ncbi.nlm.nih.gov/pubmed/19924302 http://dx.doi.org/10.1371/journal.pone.0007900 |