Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli Ulcer

Mycolactone A/B is a lipophilic macrocyclic polyketide that is the primary virulence factor produced by Mycobacterium ulcerans, a human pathogen and the causative agent of Buruli ulcer. In M. ulcerans strain Agy99 the mycolactone polyketide synthase (PKS) locus spans a 120 kb region of a 174 kb mega...

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Detalles Bibliográficos
Autores principales: Tobias, Nicholas J., Seemann, Torsten, Pidot, Sacha J., Porter, Jessica L., Marsollier, Laurent, Marion, Estelle, Letournel, Franck, Zakir, Tasnim, Azuolas, Joseph, Wallace, John R., Hong, Hui, Davies, John K., Howden, Benjamin P., Johnson, Paul D. R., Jenkin, Grant A., Stinear, Timothy P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775157/
https://www.ncbi.nlm.nih.gov/pubmed/19936295
http://dx.doi.org/10.1371/journal.pntd.0000553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775157/
https://www.ncbi.nlm.nih.gov/pubmed/19936295
http://dx.doi.org/10.1371/journal.pntd.0000553

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