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Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli Ulcer
Mycolactone A/B is a lipophilic macrocyclic polyketide that is the primary virulence factor produced by Mycobacterium ulcerans, a human pathogen and the causative agent of Buruli ulcer. In M. ulcerans strain Agy99 the mycolactone polyketide synthase (PKS) locus spans a 120 kb region of a 174 kb mega...
Autores principales: | Tobias, Nicholas J., Seemann, Torsten, Pidot, Sacha J., Porter, Jessica L., Marsollier, Laurent, Marion, Estelle, Letournel, Franck, Zakir, Tasnim, Azuolas, Joseph, Wallace, John R., Hong, Hui, Davies, John K., Howden, Benjamin P., Johnson, Paul D. R., Jenkin, Grant A., Stinear, Timothy P. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775157/ https://www.ncbi.nlm.nih.gov/pubmed/19936295 http://dx.doi.org/10.1371/journal.pntd.0000553 |
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