Catalytic Water Co-Existing with a Product Peptide in the Active Site of HIV-1 Protease Revealed by X-Ray Structure Analysis

BACKGROUND: It is known that HIV-1 protease is an important target for design of antiviral compounds in the treatment of Acquired Immuno Deficiency Syndrome (AIDS). In this context, understanding the catalytic mechanism of the enzyme is of crucial importance as transition state structure directs inh...

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Detalles Bibliográficos
Autores principales: Prashar, Vishal, Bihani, Subhash, Das, Amit, Ferrer, Jean-Luc, Hosur, Madhusoodan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775671/
https://www.ncbi.nlm.nih.gov/pubmed/19924250
http://dx.doi.org/10.1371/journal.pone.0007860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775671/
https://www.ncbi.nlm.nih.gov/pubmed/19924250
http://dx.doi.org/10.1371/journal.pone.0007860

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