Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophagic Cell Death

CML is an hematopoietic stem cell disease characterized by the t(9;22) (q34;q11) translocation encoding the oncoprotein p210BCR-ABL. The effect of acadesine (AICAR, 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) a compound with known antileukemic effect on B cell chronic lymphoblastic leukemia...

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Detalles Bibliográficos
Autores principales: Robert, Guillaume, Ben Sahra, Issam, Puissant, Alexandre, Colosetti, Pascal, Belhacene, Nathalie, Gounon, Pierre, Hofman, Paul, Bost, Fréderic, Cassuto, Jill-Patrice, Auberger, Patrick
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775681/
https://www.ncbi.nlm.nih.gov/pubmed/19924252
http://dx.doi.org/10.1371/journal.pone.0007889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775681/
https://www.ncbi.nlm.nih.gov/pubmed/19924252
http://dx.doi.org/10.1371/journal.pone.0007889

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