Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success

BACKGROUND: Multiple short hairpin RNA (shRNA) gene therapy strategies are currently being investigated for treating viral diseases such as HIV-1. It is important to use several different shRNAs to prevent the emergence of treatment-resistant strains. However, there is evidence that repeated express...

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Detalles Bibliográficos
Autores principales: Mcintyre, Glen J, Yu, Yi-Hsin, Tran, Anna, Jaramillo, Angel B, Arndt, Allison J, Millington, Michelle L, Boyd, Maureen P, Elliott, Fiona A, Shen, Sylvie W, Murray, John M, Applegate, Tanya L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775741/
https://www.ncbi.nlm.nih.gov/pubmed/19878571
http://dx.doi.org/10.1186/1743-422X-6-184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775741/
https://www.ncbi.nlm.nih.gov/pubmed/19878571
http://dx.doi.org/10.1186/1743-422X-6-184

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